Stim and Orai proteins in neuronal Ca2+ signaling and excitability
نویسندگان
چکیده
منابع مشابه
Stim and Orai proteins in neuronal Ca2+ signaling and excitability
Stim1 and Orai1 are ubiquitous proteins that have long been known to mediate Ca(2+) release-activated Ca(2+) (CRAC) current (ICRAC) and store-operated Ca(2+) entry (SOCE) only in non-excitable cells. SOCE is activated following the depletion of the endogenous Ca(2+) stores, which are mainly located within the endoplasmic reticulum (ER), to replete the intracellular Ca(2+) reservoir and engage s...
متن کاملSTIM and ORAI proteins in the nervous system.
Stromal interaction molecules (STIM) 1 and 2 are sensors of the calcium concentration in the endoplasmic reticulum. Depletion of endoplasmic reticulum calcium stores activates STIM proteins which, in turn, bind and open calcium channels in the plasma membrane formed by the proteins ORAI1, ORAI2, and ORAI3. The resulting store-operated calcium entry (SOCE), mostly controlled by the principal com...
متن کاملSTIM and ORAI proteins: crucial roles in hallmarks of cancer.
Intracellular Ca(2+) signals play a central role in several cellular processes; therefore it is not surprising that altered Ca(2+) homeostasis regulatory mechanisms lead to a variety of severe pathologies, including cancer. Stromal interaction molecules (STIM) and ORAI proteins have been identified as critical components of Ca(2+) entry in both store-dependent (SOCE mechanism) and independent b...
متن کاملSTIM and Orai Proteins in Calcium Signaling: an AJP-Cell Physiology series of Themed Reviews.
CALCIUM RELEASE-ACTIVATED CURRENTS (CRAC) were first described in the early 1990s and shown to carry out key cellular functions. As examples, CRAC channels mediate the depolarizing effect of muscarinic receptor activation in pancreatic cells (1) and promote cell cycle progression, proliferation, and acquisition of specific immune functions in T lymphocytes (2). It took another 10 years for the ...
متن کاملSTIM and Orai in hemostasis and thrombosis.
At sites of vascular injury, platelets rapidly adhere to the exposed subendothelial extracellular matrix, become activated and, together with the coagulation system, form a plug that seals the lesion. This process is essential to prevent blood loss, however, under pathological conditions it may lead to vessel occlusion. Agonist-induced elevation of intracellular Ca(2+) levels is essential for p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2015
ISSN: 1662-5102
DOI: 10.3389/fncel.2015.00153